GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Esr1 | decreases expression | EXP | | 6480464 | CTD | vinclozolin results in decreased expression of ESR1 mRNA; vinclozolin results in decreased expression of ESR1 protein | PMID:16504050 PMID:36642194 | Esr1 | affects binding | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | vinclozolin binds to ESR1 protein | PMID:14579009 | Esr1 | affects expression | ISO | Esr1 (Rattus norvegicus) | 6480464 | CTD | vinclozolin affects the expression of ESR1 mRNA | PMID:22285353 | Esr1 | increases expression | ISO | Esr1 (Rattus norvegicus) | 6480464 | CTD | vinclozolin results in increased expression of ESR1 mRNA; vinclozolin results in increased expression of ESR1 mRNA alternative form | PMID:17980475 PMID:22570695 | Esr1 | increases methylation | ISO | Esr1 (Rattus norvegicus) | 6480464 | CTD | vinclozolin results in increased methylation of ESR1 gene | PMID:31079544 | Esr1 | multiple interactions | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | vinclozolin binds to and results in increased activity of ESR1 protein; vinclozolin inhibits the reaction [Estradiol binds to ESR1 protein] | PMID:14579009 PMID:16626760 PMID:16750840 PMID:33049310 | |
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