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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10551
Species: Mus musculus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1 (alpha)
Acc ID: CHEBI:9986
Term: vinclozolin
Definition: A racemate comprising equimolar amounts of (R)- and (S)-vinclozolin. A fungicide used mainly on oilseed rape, vines, fruit and vegetables to control Botrytis, Sclerotinia and Monilia spp.
Chemical ID: MESH:C025643
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1decreases expressionEXP 6480464CTDvinclozolin results in decreased expression of ESR1 mRNA; vinclozolin results in decreased expression of ESR1 proteinPMID:16504050 PMID:36642194
Esr1affects bindingISOESR1 (Homo sapiens)6480464CTDvinclozolin binds to ESR1 proteinPMID:14579009
Esr1affects expressionISOEsr1 (Rattus norvegicus)6480464CTDvinclozolin affects the expression of ESR1 mRNAPMID:22285353
Esr1increases expressionISOEsr1 (Rattus norvegicus)6480464CTDvinclozolin results in increased expression of ESR1 mRNA; vinclozolin results in increased expression of ESR1 mRNA alternative formPMID:17980475 PMID:22570695
Esr1increases methylationISOEsr1 (Rattus norvegicus)6480464CTDvinclozolin results in increased methylation of ESR1 genePMID:31079544
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTDvinclozolin binds to and results in increased activity of ESR1 protein; vinclozolin inhibits the reaction [Estradiol binds to ESR1 protein]PMID:14579009 PMID:16626760 PMID:16750840 PMID:33049310
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