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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962 Species: Homo sapiens RGD Object: Gene Symbol: CYP3A4 Name: cytochrome P450, family 3, subfamily A, polypeptide 4

Acc ID: CHEBI:9948 Term: verapamil Definition: An L-type calcium channel blocker of the phenylalkylamine class. CasRN: 52-53-9 Chemical ID: MESH:D014700

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	naringin inhibits the reaction [CYP3A4 protein affects the metabolism of Verapamil]	PMID:16013069
affects metabolic processing	EXP		6480464	CTD	CYP3A4 protein affects the metabolism of Verapamil	PMID:15692829 PMID:15286053 PMID:16013069
decreases activity	EXP		6480464	CTD	Verapamil results in decreased activity of CYP3A4 protein	PMID:15689501 PMID:15860655
affects metabolic processing	EXP		6480464	CTD	CYP3A4 protein affects the metabolism of Verapamil	PMID:15692829 PMID:16013069 PMID:15286053
decreases activity	EXP		6480464	CTD	Verapamil results in decreased activity of CYP3A4 protein	PMID:15860655 PMID:15689501
affects metabolic processing	EXP		6480464	CTD	CYP3A4 protein affects the metabolism of Verapamil	PMID:15286053 PMID:15692829 PMID:16013069
affects metabolic processing	EXP		6480464	CTD	CYP3A4 protein affects the metabolism of Verapamil	PMID:16013069 PMID:15692829 PMID:15286053
decreases activity	ISO		6480464	CTD	Verapamil results in decreased activity of CYP3A4 protein	PMID:18420780