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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621316
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp2
Name: matrix metallopeptidase 2
Acc ID: CHEBI:9908
Term: ursolic acid
Definition: A pentacyclic triterpenoid that is urs-12-en-28-oic acid substituted by a beta-hydroxy group at position 3.
Chemical ID: MESH:C005466
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp2multiple interactionsEXP 6480464CTD2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Ursolic Acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP2 protein]]; Ursolic Acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP2 protein]PMID:27274199
Mmp2decreases expressionISOMMP2 (Homo sapiens)6480464CTDUrsolic Acid results in decreased expression of MMP2 mRNAPMID:21539908
Mmp2multiple interactionsISOMMP2 (Homo sapiens)6480464CTD[Ursolic Acid co-treated with Irinotecan] results in decreased secretion of and results in decreased activity of and results in decreased expression of MMP2 protein; [Ursolic Acid co-treated with Oleanolic Acid co-treated with Irinotecan] results in decreased secretion of and results in decreased activity of and results in decreased expression of MMP2 protein; [Ursolic Acid co-treated with Oleanolic Acid] results in decreased secretion of and results in decreased activity of and results in decreased expression of MMP2 protein; Ursolic Acid results in decreased secretion of and results in decreased activity of and results in decreased expression of MMP2 proteinPMID:36191607
Mmp2multiple interactionsISOMmp2 (Mus musculus)6480464CTD2-chloro-5-nitrobenzanilide inhibits the reaction [Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of MMP2 mRNA]]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of MMP2 protein]]; Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of MMP2 mRNA]; Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of MMP2 protein]PMID:37019307
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