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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621032
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr0b2
Name: nuclear receptor subfamily 0, group B, member 2
Acc ID: CHEBI:9907
Term: ursodeoxycholic acid
Definition: A bile acid found in the bile of bears (Ursidae) as a conjugate with taurine. Used therapeutically, it prevents the synthesis and absorption of cholesterol and can lead to the dissolution of gallstones.
Chemical ID: MESH:D014580
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr0b2increases expressionEXP 6480464CTDUrsodeoxycholic Acid results in increased expression of NR0B2 mRNAPMID:16764892 PMID:21274875
Nr0b2increases expressionISONR0B2 (Homo sapiens)6480464CTDUrsodeoxycholic Acid results in increased expression of NR0B2 mRNAPMID:18706437 PMID:25055961
Nr0b2increases expressionISONr0b2 (Mus musculus)6480464CTDUrsodeoxycholic Acid results in increased expression of NR0B2 mRNAPMID:25582706
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