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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2346
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Chrna4
Name: cholinergic receptor nicotinic alpha 4 subunit
Acc ID: CHEBI:9774
Term: tubocurarine
Definition: A benzylisoquinoline alkaloid muscle relaxant which constitutes the active component of curare.
Chemical ID: MESH:D014403
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chrna4multiple interactionsISOChrna4 (Mus musculus)6480464CTDTubocurarine inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]PMID:7756618
Chrna4multiple interactionsISOCHRNA4 (Homo sapiens)6480464CTDTubocurarine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Ethinyl Estradiol promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]]; Tubocurarine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]PMID:11711029 PMID:14645658 PMID:16931985
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