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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69147 Species: Homo sapiens RGD Object: Gene Symbol: CASP9 Name: caspase 9, apoptosis-related cysteine peptidase

Acc ID: CHEBI:9753 Term: troglitazone Definition: A chromane that has formula C24H27NO5S. CasRN: 97322-87-7 Chemical ID: MESH:C057693

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	GSK3B protein affects the susceptibility to [troglitazone results in increased expression of CASP9 protein] [N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea results in decreased activity of GSK3B protein] results in increased susceptibility to [troglitazone results in increased expression of CASP9 protein]	PMID:20540935
increases activity	EXP		6480464	CTD	troglitazone results in increased activity of CASP9 protein	PMID:14508522
increases expression	EXP		6480464	CTD	troglitazone results in increased expression of CASP9 protein	PMID:20540935