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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69115 Species: Homo sapiens RGD Object: Gene Symbol: CDKN1B Name: cyclin-dependent kinase inhibitor 1B (p27, Kip1)

Acc ID: CHEBI:9753 Term: troglitazone Definition: A chromane that has formula C24H27NO5S. CasRN: 97322-87-7 Chemical ID: MESH:C057693

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	[troglitazone co-treated with Aspirin] results in increased expression of CDKN1B protein	PMID:19908241
increases expression	EXP		6480464	CTD	troglitazone results in increased expression of CDKN1B mRNA	PMID:17143939
multiple interactions	EXP		6480464	CTD	troglitazone promotes the reaction [CDKN1B protein binds to CDK2 protein]	PMID:12717389
increases expression	EXP		6480464	CTD	troglitazone results in increased expression of CDKN1B protein	PMID:12824901 PMID:17143939 PMID:12717389 PMID:12595159
multiple interactions	EXP		6480464	CTD	[troglitazone binds to and results in increased activity of PPARG protein] which results in increased expression of and results in increased ubiquitination of CDKN1B protein [troglitazone binds to and results in increased activity of PPARG protein] which results in decreased degradation of CDKN1B protein	PMID:14618613
decreases expression	EXP		6480464	CTD	troglitazone results in decreased expression of CDKN1B mRNA troglitazone results in decreased expression of CDKN1B protein	PMID:12680223
increases expression	EXP		6480464	CTD	troglitazone results in increased expression of CDKN1B protein	PMID:16374840 PMID:17143939 PMID:12717389 PMID:11343236 PMID:12595159 PMID:12824901 PMID:12149143 PMID:14618613
multiple interactions	ISO	RGD:69062	6480464	CTD	[troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of CDKN1B protein	PMID:11318962
decreases expression	ISO	RGD:69062	6480464	CTD	troglitazone results in decreased expression of CDKN1B protein	PMID:11318962
affects response to substance	EXP		6480464	CTD	CDKN1B protein affects the susceptibility to troglitazone	PMID:11034103
increases expression	EXP		6480464	CTD	troglitazone results in increased expression of CDKN1B protein	PMID:12149143 PMID:12824901 PMID:16374840 PMID:12595159 PMID:17143939 PMID:11343236 PMID:12717389 PMID:14618613
multiple interactions	EXP		6480464	CTD	[troglitazone binds to and results in increased activity of PPARG protein] which results in increased expression of CDKN1B protein	PMID:11034103
increases expression	EXP		6480464	CTD	troglitazone results in increased expression of CDKN1B protein	PMID:17143939 PMID:11343236 PMID:12149143 PMID:16374840 PMID:14618613 PMID:12824901 PMID:12717389 PMID:12595159
increases expression	EXP		6480464	CTD	troglitazone results in increased expression of CDKN1B protein	PMID:12149143 PMID:11343236 PMID:12595159 PMID:12824901 PMID:14618613 PMID:12717389 PMID:16374840 PMID:17143939
increases expression	EXP		6480464	CTD	troglitazone results in increased expression of CDKN1B protein	PMID:11343236 PMID:17143939 PMID:16374840 PMID:12824901 PMID:12595159 PMID:14618613 PMID:12717389 PMID:12149143
increases expression	EXP		6480464	CTD	troglitazone results in increased expression of CDKN1B protein	PMID:11343236 PMID:12149143 PMID:12595159 PMID:12717389 PMID:12824901 PMID:14618613 PMID:16374840 PMID:17143939