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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69062
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdkn1b
Name: cyclin-dependent kinase inhibitor 1B
Acc ID: CHEBI:9753
Term: troglitazone
Definition: A chromane that has formula C24H27NO5S.
Chemical ID: MESH:C057693
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn1bdecreases expressionEXP 6480464CTDtroglitazone results in decreased expression of CDKN1B proteinPMID:11318962
Cdkn1bmultiple interactionsEXP 6480464CTD[troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of CDKN1B proteinPMID:11318962
Cdkn1baffects response to substanceISOCDKN1B (Homo sapiens)6480464CTDCDKN1B protein affects the susceptibility to troglitazonePMID:11034103
Cdkn1bdecreases expressionISOCDKN1B (Homo sapiens)6480464CTDtroglitazone results in decreased expression of CDKN1B mRNA; troglitazone results in decreased expression of CDKN1B proteinPMID:12680223
Cdkn1bincreases expressionISOCDKN1B (Homo sapiens)6480464CTDtroglitazone results in increased expression of CDKN1B mRNA; troglitazone results in increased expression of CDKN1B proteinPMID:11343236 PMID:12149143 PMID:12595159 PMID:12717389 PMID:12824901 PMID:14618613 PMID:16374840 PMID:17143939 PMID:25669987
Cdkn1bmultiple interactionsISOCDKN1B (Homo sapiens)6480464CTD[troglitazone binds to and results in increased activity of PPARG protein] which results in decreased degradation of CDKN1B protein; [troglitazone binds to and results in increased activity of PPARG protein] which results in increased expression of and results in increased ubiquitination of CDKN1B protein; [troglitazone binds to and results in increased activity of PPARG protein] which results in increased expression of CDKN1B protein; [troglitazone co-treated with Aspirin] results in increased expression of CDKN1B protein; troglitazone promotes the reaction [CDKN1B protein binds to CDK2 protein]PMID:11034103 PMID:12717389 PMID:14618613 PMID:19908241
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