GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cdkn1b | decreases expression | EXP | | 6480464 | CTD | troglitazone results in decreased expression of CDKN1B protein | PMID:11318962 | Cdkn1b | multiple interactions | EXP | | 6480464 | CTD | [troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of CDKN1B protein | PMID:11318962 | Cdkn1b | affects response to substance | ISO | CDKN1B (Homo sapiens) | 6480464 | CTD | CDKN1B protein affects the susceptibility to troglitazone | PMID:11034103 | Cdkn1b | decreases expression | ISO | CDKN1B (Homo sapiens) | 6480464 | CTD | troglitazone results in decreased expression of CDKN1B mRNA; troglitazone results in decreased expression of CDKN1B protein | PMID:12680223 | Cdkn1b | increases expression | ISO | CDKN1B (Homo sapiens) | 6480464 | CTD | troglitazone results in increased expression of CDKN1B mRNA; troglitazone results in increased expression of CDKN1B protein | PMID:11343236 PMID:12149143 PMID:12595159 PMID:12717389 PMID:12824901 PMID:14618613 PMID:16374840 PMID:17143939 PMID:25669987 | Cdkn1b | multiple interactions | ISO | CDKN1B (Homo sapiens) | 6480464 | CTD | [troglitazone binds to and results in increased activity of PPARG protein] which results in decreased degradation of CDKN1B protein; [troglitazone binds to and results in increased activity of PPARG protein] which results in increased expression of and results in increased ubiquitination of CDKN1B protein; [troglitazone binds to and results in increased activity of PPARG protein] which results in increased expression of CDKN1B protein; [troglitazone co-treated with Aspirin] results in increased expression of CDKN1B protein; troglitazone promotes the reaction [CDKN1B protein binds to CDK2 protein] | PMID:11034103 PMID:12717389 PMID:14618613 PMID:19908241 | |
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