GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp2c6 | decreases activity | ISO | CYP2C19 (Homo sapiens) | 6480464 | CTD | Troglitazone results in decreased activity of CYP2C19 protein | PMID:12642470 PMID:33438235 | Cyp2c6 | increases expression | ISO | Cyp2c29 (Mus musculus) | 6480464 | CTD | Troglitazone results in increased expression of CYP2C8 mRNA | PMID:28973697 | Cyp2c6 | increases expression | ISO | CYP2C19 (Homo sapiens) | 6480464 | CTD | troglitazone results in increased expression of CYP2C19 mRNA | PMID:25572481 | Cyp2c6 | increases metabolic processing | ISO | CYP2C19 (Homo sapiens) | 6480464 | CTD | CYP2C19 protein results in increased metabolism of troglitazone | PMID:19356091 | Cyp2c6 | increases response to substance | ISO | CYP2C19 (Homo sapiens) | 6480464 | CTD | CYP2C19 gene polymorphism results in increased susceptibility to troglitazone | PMID:12963435 | Cyp2c6 | multiple interactions | ISO | CYP2C19 (Homo sapiens) | 6480464 | CTD | [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to troglitazone | PMID:23397584 | | ||||||||||||||||||||||
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