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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3933 Species: Rattus norvegicus RGD Object: Gene Symbol: Ucp3 Name: uncoupling protein 3 (mitochondrial, proton carrier)

Acc ID: CHEBI:9753 Term: troglitazone Definition: A chromane that has formula C24H27NO5S. CasRN: 97322-87-7 Chemical ID: MESH:C057693

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
affects expression	ISO	RGD:11474	6480464	CTD	troglitazone affects the expression of UCP3 mRNA	PMID:12920214
increases expression	ISO	RGD:11474	6480464	CTD	troglitazone results in increased expression of UCP3 mRNA	PMID:10909982
decreases expression	EXP		6480464	CTD	troglitazone results in decreased expression of UCP3 mRNA	PMID:11118623
increases expression	EXP		6480464	CTD	troglitazone results in increased expression of UCP3 mRNA	PMID:11118623
multiple interactions	ISO	RGD:11474	6480464	CTD	Oleic Acid inhibits the reaction [troglitazone results in decreased expression of UCP3 mRNA]	PMID:11056218
decreases expression	ISO	RGD:11474	6480464	CTD	troglitazone results in decreased expression of UCP3 mRNA	PMID:11056218