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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3752
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Spp1
Name: secreted phosphoprotein 1
Acc ID: CHEBI:9753
Term: troglitazone
Definition: A chromane that has formula C24H27NO5S.
Chemical ID: MESH:C057693
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Spp1decreases expressionEXP 6480464CTDtroglitazone results in decreased expression of SPP1 mRNAPMID:21515302
Spp1decreases expressionISOSpp1 (Mus musculus)6480464CTDtroglitazone results in decreased expression of SPP1 mRNAPMID:19122273
Spp1decreases expressionISOSPP1 (Homo sapiens)6480464CTDtroglitazone results in decreased expression of SPP1 mRNAPMID:11426586
Spp1increases expressionISOSPP1 (Homo sapiens)6480464CTDtroglitazone results in increased expression of SPP1 mRNAPMID:25572481
Spp1multiple interactionsISOSPP1 (Homo sapiens)6480464CTDPPARG protein affects the reaction [troglitazone results in decreased expression of SPP1 mRNA]; troglitazone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SPP1 mRNA]PMID:11426586
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