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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10876 Species: Mus musculus RGD Object: Gene Symbol: Lpl Name: lipoprotein lipase

Acc ID: CHEBI:9753 Term: troglitazone Definition: A chromane that has formula C24H27NO5S. CasRN: 97322-87-7 Chemical ID: MESH:C057693

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	troglitazone inhibits the reaction [Calcitriol results in decreased expression of LPL mRNA] troglitazone inhibits the reaction [Tretinoin results in decreased expression of LPL mRNA]	PMID:16368784
increases expression	EXP		6480464	CTD	troglitazone results in increased expression of LPL mRNA	PMID:19122273
increases expression	ISO	RGD:70836	6480464	CTD	troglitazone results in increased expression of LPL protein	PMID:10233209
multiple interactions	ISO	RGD:70836	6480464	CTD	[troglitazone results in increased expression of LPL protein] which results in increased metabolism of Lipids	PMID:10233209
increases expression	EXP		6480464	CTD	troglitazone results in increased expression of LPL mRNA	PMID:10233209 PMID:19122273
increases expression	EXP		6480464	CTD	troglitazone results in increased expression of LPL protein	PMID:10233209
increases expression	EXP		6480464	CTD	troglitazone results in increased expression of LPL mRNA	PMID:19122273 PMID:10233209
decreases expression	ISO	RGD:3017	6480464	CTD	troglitazone results in decreased expression of LPL mRNA	PMID:21515302
multiple interactions	EXP		6480464	CTD	[troglitazone co-treated with Diethylstilbestrol] results in increased expression of LPL protein	PMID:22710028
increases expression	EXP		6480464	CTD	troglitazone results in increased expression of LPL mRNA	PMID:10233209 PMID:19122273 PMID:22710028