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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620640
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2d4
Name: cytochrome P450, family 2, subfamily d, polypeptide 4
Acc ID: CHEBI:9648
Term: tramadol
Definition: A racemate consisting of equal amounts of (R,R)- and (S,S)-tramadol. A centrally acting synthetic opioid analgesic, used (as the hydrochloride salt) to treat moderately severe pain. The (R,R)-enantiomer exhibits ten-fold higher analgesic potency than the (S,S)-enantiomer. Originally developed by Gruenenthal GmbH and launched in 1977, it was subsequently isolated from the root bark of the South African tree Nauclea latifolia.
Chemical ID: MESH:D014147
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2d4affects metabolic processingISOCYP2D6 (Homo sapiens)6480464CTDCYP2D6 gene mutant form affects the metabolism of Tramadol; CYP2D6 gene polymorphism affects the metabolism of TramadolPMID:12191703 PMID:17570739 PMID:18520597
Cyp2d4affects methylationISOCyp2d22 (Mus musculus)6480464CTDCYP2D6 protein affects the methylation of TramadolPMID:12893130
Cyp2d4affects response to substanceISOCYP2D6 (Homo sapiens)6480464CTDCYP2D6 affects the susceptibility to Tramadol; CYP2D6 gene polymorphism affects the susceptibility to Tramadol; CYP2D6 protein affects the susceptibility to TramadolPMID:16497087 PMID:16960721 PMID:31173123
Cyp2d4decreases methylationISOCYP2D6 (Homo sapiens)6480464CTDCYP2D6 protein results in decreased methylation of TramadolPMID:14624403 PMID:17361124 PMID:17470523
Cyp2d4decreases response to substanceISOCYP2D6 (Homo sapiens)6480464CTDCYP2D6 gene polymorphism results in decreased susceptibility to TramadolPMID:16960721
Cyp2d4increases metabolic processingISOCYP2D6 (Homo sapiens)6480464CTDCYP2D6 gene mutant form results in increased metabolism of Tramadol; CYP2D6 protein results in increased metabolism of TramadolPMID:18204346 PMID:18520597 PMID:18713907 PMID:29555325
Cyp2d4increases response to substanceISOCYP2D6 (Homo sapiens)6480464CTDCYP2D6 gene mutant form results in increased susceptibility to TramadolPMID:18204346
Cyp2d4multiple interactionsISOCYP2D6 (Homo sapiens)6480464CTD[CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol] which results in increased chemical synthesis of O-demethyltramadol; CYP2D6 gene polymorphism affects the metabolism of and affects the susceptibility to Tramadol; CYP2D6 protein results in increased metabolism of and results in increased activity of TramadolPMID:18204346 PMID:29555325
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