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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628714
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cd86
Name: CD86 molecule
Acc ID: CHEBI:9546
Term: thimerosal
Definition: An alkylmercury compound (approximately 49% mercury by weight) used as an antiseptic and antifungal agent.
Chemical ID: MESH:D013849
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cd86increases expressionISOCD86 (Homo sapiens)6480464CTDThimerosal results in increased expression of CD86 proteinPMID:15737199 PMID:20417223 PMID:20457211
Cd86multiple interactionsISOCD86 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [Thimerosal results in increased expression of CD86 protein]; Cysteine inhibits the reaction [Thimerosal results in increased expression of CD86 protein]; Glutathione inhibits the reaction [Thimerosal results in increased expression of CD86 protein]; Vitamin E inhibits the reaction [Thimerosal results in increased expression of CD86 protein]PMID:20417223 PMID:20457211
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