GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp3a9 | increases expression | ISO | CYP3A5 (Homo sapiens) | 6480464 | CTD | Thalidomide results in increased expression of CYP3A5 mRNA | PMID:28496040 | Cyp3a9 | increases hydroxylation | ISO | CYP3A5 (Homo sapiens) | 6480464 | CTD | CYP3A5 protein results in increased hydroxylation of Thalidomide | PMID:20443640 | Cyp3a9 | increases metabolic processing | ISO | CYP3A5 (Homo sapiens) | 6480464 | CTD | CYP3A5 protein results in increased metabolism of Thalidomide | PMID:28745489 | Cyp3a9 | multiple interactions | ISO | CYP3A5 (Homo sapiens) | 6480464 | CTD | [CYP3A5 protein results in increased hydroxylation of Thalidomide] which results in increased chemical synthesis of 5-hydroxythalidomide | PMID:20443640 | |
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