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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2561
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Erbb2
Name: erb-b2 receptor tyrosine kinase 2
Acc ID: CHEBI:94686
Term: orlistat
Definition: A carboxylic ester resulting from the formal condensation of the carboxy group of N-formyl-L-leucine with the hydroxy group of (3S,4S)-3-hexyl-4-[(2S)-2-hydroxytridecyl]oxetan-2-one. A pancreatic lipase inhibitor, it is used as an anti-obesity drug.
Chemical ID: MESH:C055122
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Erbb2affects localizationISOERBB2 (Homo sapiens)6480464CTDorlistat affects the localization of ERBB2 proteinPMID:15870086
Erbb2affects response to substanceISOERBB2 (Homo sapiens)6480464CTDERBB2 protein affects the susceptibility to orlistatPMID:15870086
Erbb2decreases expressionISOERBB2 (Homo sapiens)6480464CTDorlistat results in decreased expression of ERBB2 mRNA; orlistat results in decreased expression of ERBB2 proteinPMID:15870086
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