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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2167
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Atp1a1
Name: ATPase Na+/K+ transporting subunit alpha 1
Acc ID: CHEBI:9449
Term: terbutaline
Definition: A member of the class of phenylethanolamines that is catechol substituted at position 5 by a 2-(tert-butylamino)-1-hydroxyethyl group.
Chemical ID: MESH:D013726
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atp1a1increases expressionEXP 6480464CTDTerbutaline results in increased expression of ATP1A1 mRNA; Terbutaline results in increased expression of ATP1A1 proteinPMID:19880505 PMID:9700104
Atp1a1multiple interactionsEXP 6480464CTD[Terbutaline results in increased expression of ATP1A1 protein] which results in increased transport of Sodium; Propranolol inhibits the reaction [Terbutaline results in increased expression of ATP1A1 mRNA]PMID:19880505 PMID:9700104
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