Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2060
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adrb2
Name: adrenoceptor beta 2
Acc ID: CHEBI:9449
Term: terbutaline
Definition: A member of the class of phenylethanolamines that is catechol substituted at position 5 by a 2-(tert-butylamino)-1-hydroxyethyl group.
Chemical ID: MESH:D013726
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adrb2affects bindingEXP 6480464CTDTerbutaline binds to ADRB2 proteinPMID:19098126
Adrb2increases activityEXP 6480464CTDTerbutaline results in increased activity of ADRB2 proteinPMID:11164953 PMID:20054151
Adrb2multiple interactionsEXP 6480464CTD[Terbutaline binds to and results in increased activity of ADRB2 protein] which affects the abundance of Calcium; [Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine; [Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased uptake of Levodopa; [Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Dopamine; [Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased expression of TNF protein; [Terbutaline results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP; [Terbutaline results in increased activity of ADRB2 protein] which results in increased secretion of Histamine; [Terbutaline results in increased activity of ADRB2 protein] which results in increased transport of Chlorides; [Terbutaline results in increased activity of ADRB2 protein] which results in increased transport of Sodium; ADRB2 protein promotes the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased activity of MAPK1 protein]]; ADRB2 protein promotes the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased activity of MAPK3 protein]]; ADRB2 protein promotes the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; ADRB2 protein promotes the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; ADRB2 protein promotes the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; ADRB2 protein promotes the reaction [Terbutaline promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; CGP 20712A inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]; ICI 118551 inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased uptake of Levodopa]; ICI 118551 inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Dopamine]; ICI 118551 inhibits the reaction [Terbutaline results in increased activity of ADRB2 protein]; Pertussis Toxin promotes the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]; Terbutaline binds to and results in increased activity of ADRB2 proteinPMID:10094932 PMID:10192281 PMID:10372813 PMID:10469353 PMID:10857765 PMID:10894789 PMID:11096136 PMID:11164953 PMID:11713096 PMID:15467267 PMID:16474418 PMID:20054151
Adrb2affects response to substanceISOADRB2 (Homo sapiens)6480464CTDADRB2 gene polymorphism affects the susceptibility to Terbutaline; ADRB2 protein affects the susceptibility to Terbutaline; ADRB2 protein polymorphism affects the susceptibility to TerbutalinePMID:12563174 PMID:16153394 PMID:16395068
Adrb2decreases expressionISOADRB2 (Homo sapiens)6480464CTDTerbutaline results in decreased expression of ADRB2 proteinPMID:1280742 PMID:16980553
Adrb2increases activityISOADRB2 (Homo sapiens)6480464CTDTerbutaline results in increased activity of ADRB2 proteinPMID:34601065
Adrb2increases phosphorylationISOADRB2 (Homo sapiens)6480464CTDTerbutaline results in increased phosphorylation of ADRB2 proteinPMID:14722251 PMID:16980553
Adrb2increases response to substanceISOADRB2 (Homo sapiens)6480464CTDADRB2 protein results in increased susceptibility to Terbutaline; ADRB2 protein SNP results in increased susceptibility to TerbutalinePMID:16395068 PMID:20519311
Adrb2multiple interactionsISOAdrb2 (Mus musculus)6480464CTDADRB2 protein promotes the reaction [Terbutaline results in increased secretion of SFTPB protein]; ADRB2 protein promotes the reaction [Terbutaline results in increased secretion of SFTPC protein]; Terbutaline binds to and results in increased activity of ADRB2 proteinPMID:14565945 PMID:17430990 PMID:20061444
Adrb2multiple interactionsISOADRB2 (Homo sapiens)6480464CTD[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Isoproterenol; [Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP; [Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Potassium; [Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein; [Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein; [Terbutaline results in increased activity of ADRB2 protein] inhibits the reaction [Shiga Toxin 2 results in increased activity of CASP3 protein]; [Terbutaline results in increased activity of ADRB2 protein] inhibits the reaction [Shiga Toxin 2 results in increased activity of CASP7 protein]; [Terbutaline results in increased activity of ADRB2 protein] inhibits the reaction [Shiga Toxin 2 results in increased activity of MAPK1 protein]; [Terbutaline results in increased activity of ADRB2 protein] inhibits the reaction [Shiga Toxin 2 results in increased activity of MAPK3 protein]; ADRB2 gene polymorphism affects the reaction [Terbutaline results in increased metabolism of Lipids]; ADRB2 protein promotes the reaction [Terbutaline promotes the reaction [Lipopolysaccharides results in increased expression of CXCL8 protein]]; ADRB2 protein promotes the reaction [Terbutaline results in decreased activity of NFKB1 protein]; ADRB2 protein promotes the reaction [Terbutaline results in increased metabolism of Lipids]; ADRB2 protein promotes the reaction [Terbutaline results in increased secretion of GAST protein]; Atenolol inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [Terbutaline binds to and results in increased activity of ADRB2 protein]; ICI 118551 inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; ICI 118551 inhibits the reaction [Terbutaline binds to and results in increased activity of ADRB2 protein]; ICI 118551 inhibits the reaction [Terbutaline results in increased activity of ADRB2 protein]; Ketotifen inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Isoproterenol]; Propranolol inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Propranolol inhibits the reaction [Terbutaline binds to and results in increased activity of ADRB2 protein]; Terbutaline binds to and results in increased activity of ADRB2 protein; Terbutaline inhibits the reaction [cyanopindolol binds to ADRB2 protein]PMID:10226872 PMID:10229127 PMID:10516654 PMID:10952688 PMID:11429395 PMID:11675405 PMID:11753577 PMID:12826277 PMID:12920204 PMID:14730417 PMID:16024912 PMID:16395068 PMID:16648137 PMID:16980553 PMID:17292646 PMID:34601065 PMID:9258252 PMID:9277405
Go Back to source page   Continue to Ontology report