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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfe2l2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:9400
Term: tangeretin
Definition: A pentamethoxyflavone flavone with methoxy groups at positions 4', 5, 6 , 7 and 8.
Chemical ID: MESH:C059006
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2multiple interactionsEXP 6480464CTDtangeretin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of NFE2L2 mRNA]; tangeretin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of NFE2L2 protein]; tangeretin inhibits the reaction [Cisplatin results in increased expression of NFE2L2 protein]PMID:24995432 PMID:27616468
Nfe2l2decreases methylationISONfe2l2 (Mus musculus)6480464CTDtangeretin metabolite results in decreased methylation of NFE2L2 promoter; tangeretin results in decreased methylation of NFE2L2 promoterPMID:37517432
Nfe2l2increases expressionISONfe2l2 (Mus musculus)6480464CTDtangeretin metabolite results in increased expression of NFE2L2 mRNA; tangeretin metabolite results in increased expression of NFE2L2 protein; tangeretin results in increased expression of NFE2L2 mRNA; tangeretin results in increased expression of NFE2L2 proteinPMID:37517432
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