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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68404
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Epas1
Name: endothelial PAS domain protein 1
Acc ID: CHEBI:9381
Term: T-2 toxin
Definition: A trichothecene mycotoxin produced by fungi of the genus Fusarium. It is a common contaminant in food and feedstuffs of cereal origin and is known to cause a range of toxic effects in humans and animals.
Chemical ID: MESH:D013605
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Epas1increases expressionISOEPAS1 (Homo sapiens)6480464CTDT-2 Toxin results in increased expression of EPAS1 mRNAPMID:34581912
Epas1increases expressionISOEpas1 (Mus musculus)6480464CTDT-2 Toxin results in increased expression of EPAS1 mRNA; T-2 Toxin results in increased expression of EPAS1 proteinPMID:22800716
Epas1multiple interactionsISOEpas1 (Mus musculus)6480464CTDBAY 11-7085 inhibits the reaction [T-2 Toxin results in increased expression of EPAS1 mRNA]; BAY 11-7085 inhibits the reaction [T-2 Toxin results in increased expression of EPAS1 protein]PMID:22800716
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