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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68532 Species: Mus musculus RGD Object: Gene Symbol: Tdo2 Name: tryptophan 2,3-dioxygenase

Acc ID: CHEBI:9352 Term: sulindac Definition: A sulfoxide that has formula C20H17FO3S. CasRN: 38194-50-2 Chemical ID: MESH:D013467

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases activity	ISO	RGD:68370	6480464	CTD	Sulindac results in decreased activity of TDO2 protein	PMID:16952380
multiple interactions	ISO	RGD:68370	6480464	CTD	[Sulindac results in decreased activity of TDO2 protein] which results in decreased abundance of Dopamine [Sulindac results in decreased activity of TDO2 protein] which results in increased abundance of Serotonin	PMID:16952380