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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731580 Species: Mus musculus RGD Object: Gene Symbol: Hmgcr Name: 3-hydroxy-3-methylglutaryl-Coenzyme A reductase

Acc ID: CHEBI:9288 Term: streptozocin Definition: An antibiotic that is produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals. CasRN: 18883-66-4 Chemical ID: MESH:D013311

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:2803	6480464	CTD	Chlorogenic Acid results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein] [tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein] tetrahydrocurcumin results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein]	PMID:20696151