GENE - CHEMICAL INTERACTIONS REPORT
RGD ID:
69005
Species:
Mus musculus
RGD Object:
Gene
Symbol:
Stat3
Name:
signal transducer and activator of transcription 3
Acc ID:
CHEBI:9288
Term:
streptozocin
Definition:
An antibiotic that is produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
CasRN:
18883-66-4
Chemical ID:
MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
multiple interactions ISO RGD:3772 6480464 CTD rosiglitazone inhibits the reaction [Streptozocin results in increased phosphorylation of STAT3 protein] PMID:21599458 increases phosphorylation ISO RGD:3772 6480464 CTD Streptozocin results in increased phosphorylation of STAT3 protein PMID:21599458 multiple interactions ISO RGD:3772 6480464 CTD Enalapril inhibits the reaction [Streptozocin results in increased expression of STAT3 mRNA] PMID:19958114 multiple interactions ISO RGD:3772 6480464 CTD Simvastatin inhibits the reaction [Streptozocin results in increased phosphorylation of STAT3 protein] PMID:20821229 increases expression ISO RGD:3772 6480464 CTD Streptozocin results in increased expression of STAT3 mRNA PMID:19958114 increases phosphorylation ISO RGD:3772 6480464 CTD Streptozocin results in increased phosphorylation of STAT3 protein PMID:21599458 PMID:20821229 increases phosphorylation ISO RGD:3772 6480464 CTD Streptozocin results in increased phosphorylation of STAT3 protein PMID:20821229 PMID:21599458 multiple interactions ISO RGD:3772 6480464 CTD Acetylcysteine inhibits the reaction [Streptozocin results in decreased phosphorylation of STAT3 protein] PMID:21912612 decreases phosphorylation ISO RGD:3772 6480464 CTD Streptozocin results in decreased phosphorylation of STAT3 protein PMID:21912612 
