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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620817
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aifm1
Name: apoptosis inducing factor, mitochondria associated 1
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aifm1increases expressionEXP 6480464CTDStreptozocin results in increased expression of AIFM1 proteinPMID:19634143
Aifm1multiple interactionsEXP 6480464CTDTrientine inhibits the reaction [Streptozocin results in increased expression of AIFM1 protein]PMID:19634143
Aifm1increases expressionISOAifm1 (Mus musculus)6480464CTDStreptozocin results in increased expression of AIFM1PMID:23499715
Aifm1multiple interactionsISOAifm1 (Mus musculus)6480464CTD[Streptozocin co-treated with NQO1 protein mutant form] results in increased expression of AIFM1 protein; FGF21 protein affects the reaction [Streptozocin results in increased expression of AIFM1]PMID:23458895 PMID:23499715
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