GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nfe2l2 | increases expression | ISO | Nfe2l2 (Mus musculus) | 156430337 | RGD | streptozocin increases expression of Nfe2l2 protein in heart | | Nfe2l2 | affects localization | EXP | | 6480464 | CTD | Streptozocin affects the localization of NFE2L2 protein | PMID:21799698 PMID:24740756 PMID:25541178 | Nfe2l2 | decreases expression | EXP | | 6480464 | CTD | Streptozocin results in decreased expression of NFE2L2 mRNA; Streptozocin results in decreased expression of NFE2L2 protein | PMID:22790776 PMID:23453443 PMID:24740756 PMID:31173751 PMID:32202043 PMID:32662907 PMID:33639173 PMID:35478295 | Nfe2l2 | increases expression | EXP | | 6480464 | CTD | Streptozocin results in increased expression of NFE2L2 mRNA; Streptozocin results in increased expression of NFE2L2 protein | PMID:20399799 PMID:30817903 | Nfe2l2 | multiple interactions | EXP | | 6480464 | CTD | 2-tert-butylhydroquinone inhibits the reaction [Streptozocin results in decreased expression of NFE2L2 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [Streptozocin results in decreased expression of NFE2L2 protein]; 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of NFE2L2 mRNA]; 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of NFE2L2 protein]; 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of NFE2L2 protein]; [Dietary Fats co-treated with Streptozocin] results in decreased expression of NFE2L2 protein; [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NFE2L2 protein]; [Streptozocin co-treated with Dietary Fats] results in decreased expression of NFE2L2 protein; [Streptozocin co-treated with Niacinamide] results in decreased expression of NFE2L2 mRNA; [Streptozocin co-treated with Niacinamide] results in decreased expression of NFE2L2 protein; allyl isothiocyanate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NFE2L2 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [NFE2L2 protein inhibits the reaction [Streptozocin results in increased expression of USP15 protein]]; chromium histidinate inhibits the reaction [Streptozocin results in decreased expression of NFE2L2 protein]; Curcumin inhibits the reaction [Streptozocin affects the localization of NFE2L2 protein]; diallyl trisulfide inhibits the reaction [Streptozocin results in decreased expression of NFE2L2 protein]; Dimethyl Fumarate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NFE2L2 protein]; diphenyldiselenide inhibits the reaction [Streptozocin results in decreased expression of NFE2L2 mRNA]; diphenyldiselenide inhibits the reaction [Streptozocin results in decreased expression of NFE2L2 protein]; G6PD protein promotes the reaction [Streptozocin results in decreased expression of NFE2L2 mRNA]; G6PD protein promotes the reaction [Streptozocin results in decreased expression of NFE2L2 protein]; Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of NFE2L2 mRNA]; Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of NFE2L2 protein]; Glyburide inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NFE2L2 protein]; Glyburide inhibits the reaction [Streptozocin results in increased expression of NFE2L2 mRNA]; isoquercitrin inhibits the reaction [Streptozocin results in increased expression of NFE2L2 mRNA]; Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NFE2L2 protein]; Metformin inhibits the reaction [Streptozocin results in decreased expression of NFE2L2 protein]; NFE2L2 protein inhibits the reaction [Streptozocin results in decreased expression of G6PD mRNA]; NFE2L2 protein inhibits the reaction [Streptozocin results in decreased expression of G6PD protein]; NFE2L2 protein inhibits the reaction [Streptozocin results in increased expression of USP15 protein]; palbinone inhibits the reaction [Streptozocin results in decreased expression of NFE2L2 mRNA]; picolinic acid inhibits the reaction [Streptozocin results in decreased expression of NFE2L2 protein]; Plant Extracts inhibits the reaction [Streptozocin affects the localization of NFE2L2 protein]; Resveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of NFE2L2 mRNA]; Resveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of NFE2L2 protein]; Resveratrol inhibits the reaction [Streptozocin results in decreased expression of NFE2L2 mRNA]; Resveratrol promotes the reaction [Streptozocin affects the localization of NFE2L2 protein]; rhapontin inhibits the reaction [Streptozocin results in decreased expression of NFE2L2 mRNA]; rhapontin inhibits the reaction [Streptozocin results in decreased expression of NFE2L2 protein]; Streptozocin results in decreased expression of and results in decreased phosphorylation of NFE2L2 protein; STUB1 inhibits the reaction [Streptozocin results in decreased expression of and results in decreased phosphorylation of NFE2L2 protein]; sulforaphane inhibits the reaction [Streptozocin results in decreased expression of NFE2L2 mRNA]; sulforaphane inhibits the reaction [Streptozocin results in decreased expression of NFE2L2 protein]; USP15 protein inhibits the reaction [Streptozocin results in decreased expression of NFE2L2 mRNA]; USP15 protein inhibits the reaction [Streptozocin results in decreased expression of NFE2L2 protein] | PMID:20399799 PMID:21439372 PMID:21799698 PMID:22790776 PMID:23453443 PMID:24740756 PMID:25541178 PMID:30817903 PMID:30927557 PMID:31173751 PMID:31726037 PMID:32202043 PMID:32662907 PMID:33639173 PMID:35442559 PMID:35478295 PMID:36999408 | Nfe2l2 | affects response to substance | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | NFE2L2 protein affects the susceptibility to Streptozocin | PMID:20086057 | Nfe2l2 | decreases expression | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | Streptozocin results in decreased expression of NFE2L2 mRNA; Streptozocin results in decreased expression of NFE2L2 protein | PMID:24967692 PMID:26700463 | Nfe2l2 | increases activity | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | Streptozocin results in increased activity of NFE2L2 protein | PMID:30203046 | Nfe2l2 | increases expression | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | Streptozocin results in increased expression of NFE2L2 mRNA | PMID:23319174 | Nfe2l2 | multiple interactions | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | 2,5-dihydroxybenzoic acid promotes the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of NFE2L2 protein]; [Acrylamide co-treated with Streptozocin] results in decreased expression of NFE2L2 mRNA; [Dietary Fats co-treated with Streptozocin] results in decreased expression of NFE2L2 mRNA; [Dietary Fats co-treated with Streptozocin] results in decreased expression of NFE2L2 protein; [NFE2L2 protein mutant form co-treated with Streptozocin] results in increased abundance of 3-Hydroxybutyric Acid; [NFE2L2 protein mutant form co-treated with Streptozocin] results in increased abundance of Glucose; [NFE2L2 protein mutant form co-treated with Streptozocin] results in increased abundance of Triglycerides; [Streptozocin co-treated with Dietary Fats] results in decreased expression of NFE2L2 mRNA; [Streptozocin co-treated with Dietary Fats] results in decreased expression of NFE2L2 protein; [Streptozocin co-treated with Niacinamide] results in increased expression of NFE2L2 protein; [Streptozocin co-treated with sulforaphane] results in increased expression of NFE2L2; ginsenoside Rh4 inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of NFE2L2 mRNA]; ginsenoside Rh4 inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of NFE2L2 protein]; Metformin promotes the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of NFE2L2 protein]; NFE2L2 protein affects the reaction [Streptozocin results in decreased abundance of Glycogen]; pterostilbene inhibits the reaction [Streptozocin results in decreased expression of NFE2L2 protein]; pterostilbene inhibits the reaction [Streptozocin results in decreased phosphorylation of and affects the localization of NFE2L2 protein]; Streptozocin results in decreased expression of and results in decreased phosphorylation of NFE2L2 protein; Streptozocin results in decreased phosphorylation of and affects the localization of NFE2L2 protein; sulforaphane inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NFE2L2 mRNA]; sulforaphane inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NFE2L2 protein]; sulforaphane inhibits the reaction [Streptozocin results in decreased expression of and results in decreased phosphorylation of NFE2L2 protein]; sulforaphane inhibits the reaction [Streptozocin results in decreased expression of NFE2L2 mRNA] | PMID:20086057 PMID:22023613 PMID:24707343 PMID:24967692 PMID:26700463 PMID:33359794 PMID:34896238 PMID:37120126 | | ||||||||||||||||||||||
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