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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3802
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Syp
Name: synaptophysin
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sypdecreases expressionEXP 6480464CTDStreptozocin results in decreased expression of SYP mRNA; Streptozocin results in decreased expression of SYP proteinPMID:22062134 PMID:38049026
Sypmultiple interactionsEXP 6480464CTDfasudil inhibits the reaction [Streptozocin results in decreased expression of SYP mRNA]; fasudil inhibits the reaction [Streptozocin results in decreased expression of SYP protein]; Vitamin B 12 inhibits the reaction [Streptozocin results in decreased expression of SYP protein]PMID:22062134 PMID:38049026
Sypdecreases expressionISOSyp (Mus musculus)6480464CTDStreptozocin results in decreased expression of SYP proteinPMID:28499986
Sypincreases expressionISOSyp (Mus musculus)6480464CTDStreptozocin results in increased expression of SYP mRNAPMID:18487452
Sypmultiple interactionsISOSyp (Mus musculus)6480464CTDAcetylcysteine inhibits the reaction [Streptozocin results in decreased expression of SYP protein]; Physostigmine inhibits the reaction [Streptozocin results in decreased expression of SYP protein]; telmisartan inhibits the reaction [Streptozocin results in decreased expression of SYP protein]; Valsartan inhibits the reaction [Streptozocin results in decreased expression of SYP protein]PMID:18487452 PMID:28499986
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