GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Stat3 | decreases phosphorylation | EXP | | 6480464 | CTD | Streptozocin results in decreased phosphorylation of STAT3 protein | PMID:21912612 PMID:24810525 | Stat3 | increases expression | EXP | | 6480464 | CTD | Streptozocin results in increased expression of STAT3 mRNA; Streptozocin results in increased expression of STAT3 protein | PMID:19958114 PMID:36650709 | Stat3 | increases phosphorylation | EXP | | 6480464 | CTD | Streptozocin results in increased phosphorylation of STAT3 protein | PMID:20821229 PMID:21599458 PMID:29291386 PMID:34455488 | Stat3 | multiple interactions | EXP | | 6480464 | CTD | 7-hydroxycoumarin inhibits the reaction [Streptozocin results in increased expression of STAT3 mRNA]; 7-hydroxycoumarin inhibits the reaction [Streptozocin results in increased expression of STAT3 protein]; Acetylcysteine inhibits the reaction [Streptozocin results in decreased phosphorylation of STAT3 protein]; Allopurinol promotes the reaction [Acetylcysteine inhibits the reaction [Streptozocin results in decreased phosphorylation of STAT3 protein]]; Enalapril inhibits the reaction [Streptozocin results in increased expression of STAT3 mRNA]; Enalapril inhibits the reaction [Streptozocin results in increased expression of STAT3 protein]; nifuroxazide inhibits the reaction [Streptozocin results in increased phosphorylation of STAT3 protein]; Phosphocreatine inhibits the reaction [Streptozocin results in increased phosphorylation of STAT3 protein]; Propofol promotes the reaction [Streptozocin results in decreased phosphorylation of STAT3 protein]; Rosiglitazone inhibits the reaction [Streptozocin results in increased phosphorylation of STAT3 protein]; Simvastatin inhibits the reaction [Streptozocin results in increased phosphorylation of STAT3 protein] | PMID:19958114 PMID:20821229 PMID:21599458 PMID:21912612 PMID:24810525 PMID:29291386 PMID:34455488 PMID:36650709 | | ||||||||||||||||||||||
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