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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3731 Species: Rattus norvegicus RGD Object: Gene Symbol: Sod1 Name: superoxide dismutase 1, soluble

Acc ID: CHEBI:9288 Term: streptozocin Definition: An antibiotic that is produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals. CasRN: 18883-66-4 Chemical ID: MESH:D013311

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:11329	6480464	CTD	Streptozocin results in increased expression of SOD1 mRNA	PMID:15298345
affects expression	ISO	RGD:11329	6480464	CTD	Streptozocin affects the expression of SOD1 mRNA	PMID:18583417
decreases expression	EXP		6480464	CTD	Streptozocin results in decreased expression of SOD1 protein	PMID:19634143
multiple interactions	EXP		6480464	CTD	Trientine inhibits the reaction [Streptozocin results in decreased expression of SOD1 protein]	PMID:19634143
multiple interactions	EXP		6480464	CTD	arjunolic acid inhibits the reaction [Streptozocin results in decreased activity of SOD1 protein]	PMID:20053369
decreases activity	EXP		6480464	CTD	Streptozocin results in decreased activity of SOD1 protein	PMID:20053369