GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Pparg | decreases expression | EXP | | 6480464 | CTD | Streptozocin results in decreased expression of PPARG; Streptozocin results in decreased expression of PPARG mRNA; Streptozocin results in decreased expression of PPARG protein | PMID:12967931 PMID:16980342 PMID:21450970 PMID:24136780 PMID:25246140 PMID:29223569 PMID:29953732 PMID:34175429 PMID:37044004 | Pparg | increases expression | EXP | | 6480464 | CTD | Streptozocin results in increased expression of PPARG mRNA; Streptozocin results in increased expression of PPARG protein | PMID:20219977 PMID:21450970 | Pparg | multiple interactions | EXP | | 6480464 | CTD | 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Calcitriol inhibits the reaction [Streptozocin results in decreased expression of PPARG mRNA]]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Calcitriol inhibits the reaction [Streptozocin results in decreased expression of PPARG protein]]; 2-chloro-5-nitrobenzanilide promotes the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of PPARG protein]; [Streptozocin co-treated with Dietary Fats] results in decreased expression of PPARG mRNA; [Streptozocin co-treated with Dietary Fats] results in decreased expression of PPARG protein; [Streptozocin co-treated with Isoproterenol] affects the expression of PPARG protein; [Streptozocin co-treated with Niacinamide] results in decreased expression of PPARG protein; allyl isothiocyanate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of PPARG protein]; Bezafibrate inhibits the reaction [Streptozocin results in decreased expression of PPARG mRNA]; Calcitriol inhibits the reaction [Streptozocin results in decreased expression of PPARG mRNA]; Calcitriol inhibits the reaction [Streptozocin results in decreased expression of PPARG protein]; chebulagic acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of PPARG protein]; esculetin inhibits the reaction [Streptozocin results in decreased expression of PPARG protein]; esculetin inhibits the reaction [Streptozocin results in increased expression of PPARG protein]; eupafolin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of PPARG protein]; Ficusin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of PPARG mRNA]; Glyburide inhibits the reaction [Streptozocin results in decreased expression of PPARG mRNA]; Glyburide inhibits the reaction [Streptozocin results in decreased expression of PPARG protein]; Hesperidin inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of PPARG protein]]; Hesperidin inhibits the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of PPARG protein]; INS protein promotes the reaction [Streptozocin results in increased expression of PPARG mRNA]; mangiferin inhibits the reaction [Streptozocin results in decreased expression of PPARG mRNA]; mangiferin inhibits the reaction [Streptozocin results in decreased expression of PPARG protein]; naringenin inhibits the reaction [Streptozocin results in decreased expression of PPARG mRNA]; naringenin inhibits the reaction [Streptozocin results in decreased expression of PPARG protein]; Olive Oil inhibits the reaction [Streptozocin results in decreased expression of PPARG mRNA]; Pioglitazone inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of PPARG mRNA]; Pioglitazone inhibits the reaction [Streptozocin results in decreased expression of PPARG protein]; Quercetin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of PPARG protein]; Rosiglitazone inhibits the reaction [Streptozocin results in decreased expression of PPARG] | PMID:12967931 PMID:20219977 PMID:21450970 PMID:24136780 PMID:24954035 PMID:25246140 PMID:27350165 PMID:29223569 PMID:29953732 PMID:30927557 PMID:34470562 PMID:37044004 PMID:37566541 | Pparg | decreases expression | ISO | Pparg (Mus musculus) | 6480464 | CTD | Streptozocin results in decreased expression of PPARG mRNA; Streptozocin results in decreased expression of PPARG protein | PMID:21381899 PMID:30642005 | Pparg | increases expression | ISO | Pparg (Mus musculus) | 6480464 | CTD | Streptozocin results in increased expression of PPARG mRNA | PMID:23319174 | Pparg | multiple interactions | ISO | Pparg (Mus musculus) | 6480464 | CTD | [Dietary Fats co-treated with Streptozocin] results in decreased expression of PPARG mRNA; [Dietary Fats co-treated with Streptozocin] results in increased expression of PPARG mRNA; [Streptozocin co-treated with Dietary Fats co-treated with Carboxymethylcellulose Sodium] results in decreased expression of PPARG protein; [Streptozocin co-treated with Dietary Fats co-treated with Diethylhexyl Phthalate] results in decreased expression of PPARG protein; [Streptozocin co-treated with Dietary Fats] results in decreased expression of PPARG protein; esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of PPARG mRNA]; ginsenoside Rh4 inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of PPARG mRNA]; MIR29A mRNA inhibits the reaction [Streptozocin results in decreased expression of PPARG mRNA]; MIR29A mRNA inhibits the reaction [Streptozocin results in decreased expression of PPARG protein]; naringenin inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Carboxymethylcellulose Sodium] results in decreased expression of PPARG protein]; Telmisartan inhibits the reaction [Streptozocin results in decreased expression of PPARG protein] | PMID:21381899 PMID:27769711 PMID:30642005 PMID:31063766 PMID:33359794 PMID:33484791 | | ||||||||||||||||||||||
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