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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3193
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nppa
Name: natriuretic peptide A
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nppaincreases expressionEXP 6480464CTDStreptozocin results in increased expression of NPPA mRNA; Streptozocin results in increased expression of NPPA proteinPMID:16409969 PMID:16980342
Nppamultiple interactionsEXP 6480464CTDDrugs, Chinese Herbal inhibits the reaction [Streptozocin results in increased expression of NPPA protein]PMID:16409969
Nppaincreases expressionISONppa (Mus musculus)6480464CTDStreptozocin results in increased expression of NPPA mRNAPMID:18945756
Nppamultiple interactionsISONppa (Mus musculus)6480464CTDSLC25A4 protein inhibits the reaction [Streptozocin results in increased expression of NPPA mRNA]PMID:18945756
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