GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ace | increases expression | EXP | | 6480464 | CTD | Streptozocin results in increased expression of ACE mRNA; Streptozocin results in increased expression of ACE protein | PMID:15793251 PMID:16979161 PMID:22191573 PMID:23733546 PMID:29682576 | Ace | multiple interactions | EXP | | 6480464 | CTD | [INS1 protein co-treated with Pravastatin] inhibits the reaction [Streptozocin results in increased expression of ACE protein]; Bezafibrate inhibits the reaction [Streptozocin results in increased expression of ACE mRNA]; Bezafibrate inhibits the reaction [Streptozocin results in increased expression of ACE protein]; Enalapril inhibits the reaction [Streptozocin results in increased expression of ACE mRNA]; Enalapril inhibits the reaction [Streptozocin results in increased expression of ACE protein]; Pioglitazone inhibits the reaction [Streptozocin results in increased expression of ACE mRNA]; Pioglitazone inhibits the reaction [Streptozocin results in increased expression of ACE protein]; Resveratrol inhibits the reaction [Streptozocin results in increased expression of ACE mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of ACE mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of ACE protein] | PMID:16979161 PMID:22191573 PMID:23733546 PMID:29682576 | Ace | increases activity | ISO | Ace (Mus musculus) | 6480464 | CTD | Streptozocin results in increased activity of ACE protein | PMID:28468961 | Ace | increases expression | ISO | Ace (Mus musculus) | 6480464 | CTD | Streptozocin results in increased expression of ACE protein | PMID:29266779 | Ace | multiple interactions | ISO | Ace (Mus musculus) | 6480464 | CTD | 2,5-dihydroxybenzoic acid inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of ACE mRNA]; [Streptozocin co-treated with Niacinamide] results in increased expression of ACE mRNA; CEBPB protein inhibits the reaction [Streptozocin results in increased expression of ACE protein]; Metformin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of ACE mRNA] | PMID:29266779 PMID:37120126 | |
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