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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2493
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ace
Name: angiotensin I converting enzyme
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aceincreases expressionEXP 6480464CTDStreptozocin results in increased expression of ACE mRNA; Streptozocin results in increased expression of ACE proteinPMID:15793251 PMID:16979161 PMID:22191573 PMID:23733546 PMID:29682576
Acemultiple interactionsEXP 6480464CTD[INS1 protein co-treated with Pravastatin] inhibits the reaction [Streptozocin results in increased expression of ACE protein]; Bezafibrate inhibits the reaction [Streptozocin results in increased expression of ACE mRNA]; Bezafibrate inhibits the reaction [Streptozocin results in increased expression of ACE protein]; Enalapril inhibits the reaction [Streptozocin results in increased expression of ACE mRNA]; Enalapril inhibits the reaction [Streptozocin results in increased expression of ACE protein]; Pioglitazone inhibits the reaction [Streptozocin results in increased expression of ACE mRNA]; Pioglitazone inhibits the reaction [Streptozocin results in increased expression of ACE protein]; Resveratrol inhibits the reaction [Streptozocin results in increased expression of ACE mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of ACE mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of ACE protein]PMID:16979161 PMID:22191573 PMID:23733546 PMID:29682576
Aceincreases activityISOAce (Mus musculus)6480464CTDStreptozocin results in increased activity of ACE proteinPMID:28468961
Aceincreases expressionISOAce (Mus musculus)6480464CTDStreptozocin results in increased expression of ACE proteinPMID:29266779
Acemultiple interactionsISOAce (Mus musculus)6480464CTD2,5-dihydroxybenzoic acid inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of ACE mRNA]; [Streptozocin co-treated with Niacinamide] results in increased expression of ACE mRNA; CEBPB protein inhibits the reaction [Streptozocin results in increased expression of ACE protein]; Metformin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of ACE mRNA]PMID:29266779 PMID:37120126
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