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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2072
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Agtr2
Name: angiotensin II receptor, type 2
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Agtr2increases expressionEXP 6480464CTDStreptozocin results in increased expression of AGTR2 mRNA; Streptozocin results in increased expression of AGTR2 proteinPMID:15587404
Agtr2multiple interactionsEXP 6480464CTD[Streptozocin co-treated with Dietary Fats] results in increased expression of AGTR2 mRNA; Drugs, Chinese Herbal inhibits the reaction [Streptozocin results in increased expression of AGTR2 mRNA]; Drugs, Chinese Herbal inhibits the reaction [Streptozocin results in increased expression of AGTR2 protein]; esculetin promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of AGTR2 mRNA]PMID:15587404 PMID:28946194
Agtr2increases expressionISOAgtr2 (Mus musculus)6480464CTDStreptozocin results in increased expression of AGTR2 mRNA; Streptozocin results in increased expression of AGTR2 proteinPMID:17724226 PMID:29266779
Agtr2multiple interactionsISOAgtr2 (Mus musculus)6480464CTDCEBPB protein inhibits the reaction [Streptozocin results in increased expression of AGTR2 protein]; Valsartan inhibits the reaction [Streptozocin results in increased expression of AGTR2 protein]PMID:29266779
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