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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1553531 Species: Mus musculus RGD Object: Gene Symbol: Rac1 Name: RAS-related C3 botulinum substrate 1

Acc ID: CHEBI:9288 Term: streptozocin Definition: An antibiotic that is produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals. CasRN: 18883-66-4 Chemical ID: MESH:D013311

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	atorvastatin inhibits the reaction [Streptozocin results in increased activity of and results in increased localization of RAC1 protein]	PMID:17279352
multiple interactions	ISO	RGD:619755	6480464	CTD	atorvastatin inhibits the reaction [Streptozocin results in increased activity of RAC1 protein]	PMID:17589825
increases activity	ISO	RGD:619755	6480464	CTD	Streptozocin results in increased activity of RAC1 protein	PMID:17589825