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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309196 Species: Rattus norvegicus RGD Object: Gene Symbol: Foxo3 Name: forkhead box O3

Acc ID: CHEBI:9288 Term: streptozocin Definition: An antibiotic that is produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals. CasRN: 18883-66-4 Chemical ID: MESH:D013311

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	EXP		6480464	CTD	Streptozocin results in decreased expression of FOXO3 protein	PMID:18703049
increases expression	ISO	RGD:1553155	6480464	CTD	Streptozocin results in increased expression of FOXO3 protein modified form	PMID:17082237
increases expression	EXP		6480464	CTD	Streptozocin results in increased expression of FOXO3 protein modified form	PMID:17082237