GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp2e1 | decreases activity | EXP | | 6480464 | CTD | Chlormethiazole results in decreased activity of CYP2E1 protein | PMID:16330492 | Cyp2e1 | decreases expression | EXP | | 6480464 | CTD | Chlormethiazole results in decreased expression of CYP2E1 mRNA; Chlormethiazole results in decreased expression of CYP2E1 protein | PMID:10751552 PMID:7601153 | Cyp2e1 | multiple interactions | EXP | | 6480464 | CTD | Chlormethiazole inhibits the reaction [CYP2E1 protein results in increased metabolism of 4-nitrophenol]; Chlormethiazole inhibits the reaction [CYP2E1 protein results in increased metabolism of Carbon Tetrachloride] | PMID:7601153 | Cyp2e1 | decreases activity | ISO | CYP2E1 (Homo sapiens) | 6480464 | CTD | Chlormethiazole results in decreased activity of CYP2E1 protein | PMID:26599973 | Cyp2e1 | decreases expression | ISO | CYP2E1 (Homo sapiens) | 6480464 | CTD | Chlormethiazole results in decreased expression of CYP2E1 protein | PMID:16963249 | Cyp2e1 | multiple interactions | ISO | Cyp2e1 (Mus musculus) | 6480464 | CTD | Chlormethiazole inhibits the reaction [cyanoginosin LR results in increased expression of CYP2E1 mRNA]; Chlormethiazole inhibits the reaction [Ethanol results in increased activity of CYP2E1 protein]; Chlormethiazole inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein] | PMID:21684301 PMID:22552773 PMID:24892905 | Cyp2e1 | multiple interactions | ISO | CYP2E1 (Homo sapiens) | 6480464 | CTD | [Chlormethiazole results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; Chlormethiazole inhibits the reaction [Docosahexaenoic Acids results in increased expression of CYP2E1 protein] | PMID:16963249 PMID:26599973 | |
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