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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2475
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2e1
Name: cytochrome P450, family 2, subfamily e, polypeptide 1
Acc ID: CHEBI:92875
Term: 5-(2-chloroethyl)-4-methylthiazole
Definition: A thiazole that has formula C6H8ClNS.
Chemical ID: MESH:D002719
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2e1decreases activityEXP 6480464CTDChlormethiazole results in decreased activity of CYP2E1 proteinPMID:16330492
Cyp2e1decreases expressionEXP 6480464CTDChlormethiazole results in decreased expression of CYP2E1 mRNA; Chlormethiazole results in decreased expression of CYP2E1 proteinPMID:10751552 PMID:7601153
Cyp2e1multiple interactionsEXP 6480464CTDChlormethiazole inhibits the reaction [CYP2E1 protein results in increased metabolism of 4-nitrophenol]; Chlormethiazole inhibits the reaction [CYP2E1 protein results in increased metabolism of Carbon Tetrachloride]PMID:7601153
Cyp2e1decreases activityISOCYP2E1 (Homo sapiens)6480464CTDChlormethiazole results in decreased activity of CYP2E1 proteinPMID:26599973
Cyp2e1decreases expressionISOCYP2E1 (Homo sapiens)6480464CTDChlormethiazole results in decreased expression of CYP2E1 proteinPMID:16963249
Cyp2e1multiple interactionsISOCyp2e1 (Mus musculus)6480464CTDChlormethiazole inhibits the reaction [cyanoginosin LR results in increased expression of CYP2E1 mRNA]; Chlormethiazole inhibits the reaction [Ethanol results in increased activity of CYP2E1 protein]; Chlormethiazole inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]PMID:21684301 PMID:22552773 PMID:24892905
Cyp2e1multiple interactionsISOCYP2E1 (Homo sapiens)6480464CTD[Chlormethiazole results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; Chlormethiazole inhibits the reaction [Docosahexaenoic Acids results in increased expression of CYP2E1 protein]PMID:16963249 PMID:26599973
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