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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69057
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1i2
Name: nuclear receptor subfamily 1, group I, member 2
Acc ID: CHEBI:9241
Term: spironolactone
Definition: A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Chemical ID: MESH:D013148
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1i2multiple interactionsEXP 6480464CTDNR1I2 protein promotes the reaction [Spironolactone results in increased expression of CYP3A23-3A1 mRNA]PMID:11752103
Nr1i2increases expressionISONr1i2 (Mus musculus)6480464CTDSpironolactone results in increased expression of NR1I2 mRNAPMID:17627975
Nr1i2multiple interactionsISONR1I2 (Homo sapiens)6480464CTDNR1I2 affects the reaction [Spironolactone results in increased expression of ABCB1 protein]; Spironolactone binds to and results in increased activity of NR1I2 proteinPMID:16054614 PMID:21459122 PMID:33049310
Nr1i2multiple interactionsISONr1i2 (Mus musculus)6480464CTD[Spironolactone binds to NR1I2 protein] which results in increased expression of ABCC3 mRNA; Spironolactone binds to and results in increased activity of NR1I2 proteinPMID:15833929 PMID:15919853 PMID:33049310
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