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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619930
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb11
Name: ATP binding cassette subfamily B member 11
Acc ID: CHEBI:9241
Term: spironolactone
Definition: A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Chemical ID: MESH:D013148
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb11decreases activityISOABCB11 (Homo sapiens)6480464CTDSpironolactone results in decreased activity of ABCB11 proteinPMID:24014644
Abcb11multiple interactionsISOABCB11 (Homo sapiens)6480464CTDSpironolactone inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]PMID:24014644
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