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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2366 Species: Rattus norvegicus RGD Object: Gene Symbol: Abcc2 Name: ATP-binding cassette, subfamily C (CFTR/MRP), member 2

Acc ID: CHEBI:9241 Term: spironolactone Definition: A steroid lactone that has formula C24H32O4S. CasRN: 52-01-7 Chemical ID: MESH:D013148

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	[Ethinyl Estradiol co-treated with Spironolactone] results in increased expression of ABCC2 protein	PMID:17686906
increases expression	EXP		6480464	CTD	Spironolactone results in increased expression of ABCC2 mRNA	PMID:17686906
increases expression	EXP		6480464	CTD	Spironolactone results in increased expression of ABCC2 protein	PMID:15652244 PMID:17686906
increases expression	EXP		6480464	CTD	Spironolactone results in increased expression of ABCC2 protein	PMID:17686906 PMID:15652244