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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2069
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Agt
Name: angiotensinogen
Acc ID: CHEBI:9241
Term: spironolactone
Definition: A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Chemical ID: MESH:D013148
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Agtdecreases expressionEXP 6480464CTDSpironolactone results in decreased expression of AGT protein modified formPMID:19114643
Agtmultiple interactionsEXP 6480464CTDDactinomycin promotes the reaction [Spironolactone inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]]; Spironolactone inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]PMID:23288202
Agtincreases expressionISOAGT (Homo sapiens)6480464CTDSpironolactone results in increased expression of AGT protein modified formPMID:7357812 PMID:9595286
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