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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10458 Species: Mus musculus RGD Object: Gene Symbol: Cyp7a1 Name: cytochrome P450, family 7, subfamily a, polypeptide 1

Acc ID: CHEBI:9241 Term: spironolactone Definition: A steroid lactone that has formula C24H32O4S. CasRN: 52-01-7 Chemical ID: MESH:D013148

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases activity	ISO	RGD:2482	6480464	CTD	Spironolactone results in decreased activity of CYP7A1 protein	PMID:15652244