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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70494 Species: Rattus norvegicus RGD Object: Gene Symbol: Tert Name: telomerase reverse transcriptase

Acc ID: CHEBI:9168 Term: sirolimus Definition: A macrolide isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent. CasRN: 53123-88-9 Chemical ID: MESH:D020123

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:1353510	6480464	CTD	Sirolimus results in decreased expression of TERT protein	PMID:17996122
decreases expression	ISO	RGD:1353510	6480464	CTD	Sirolimus results in decreased expression of TERT mRNA	PMID:12939469 PMID:16455087 PMID:20863555
decreases expression	ISO	RGD:1353510	6480464	CTD	Sirolimus results in decreased expression of TERT mRNA	PMID:16455087 PMID:12939469 PMID:20863555
decreases expression	ISO	RGD:1353510	6480464	CTD	Sirolimus results in decreased expression of TERT mRNA	PMID:12939469 PMID:20863555 PMID:16455087
decreases expression	ISO	RGD:1353510	6480464	CTD	Sirolimus results in decreased expression of TERT mRNA	PMID:20863555 PMID:16455087 PMID:12939469
decreases expression	ISO	RGD:1353510	6480464	CTD	Sirolimus results in decreased expression of TERT mRNA	PMID:16455087 PMID:20863555 PMID:12939469