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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69005 Species: Mus musculus RGD Object: Gene Symbol: Stat3 Name: signal transducer and activator of transcription 3

Acc ID: CHEBI:9168 Term: sirolimus Definition: A macrolide isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent. CasRN: 53123-88-9 Chemical ID: MESH:D020123

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases phosphorylation	ISO	RGD:737517	6480464	CTD	Sirolimus results in decreased phosphorylation of STAT3 protein	PMID:20038814
multiple interactions	ISO	RGD:737517	6480464	CTD	Sirolimus inhibits the reaction [IFNG protein results in decreased phosphorylation of STAT3 protein]	PMID:16427044
decreases phosphorylation	ISO	RGD:3772	6480464	CTD	Sirolimus results in decreased phosphorylation of STAT3 protein	PMID:16391472