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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3772
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Stat3
Name: signal transducer and activator of transcription 3
Acc ID: CHEBI:9168
Term: sirolimus
Definition: A macrolide lactam isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent.
Chemical ID: MESH:D020123
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stat3decreases phosphorylationEXP 6480464CTDSirolimus results in decreased phosphorylation of STAT3 proteinPMID:16391472
Stat3multiple interactionsEXP 6480464CTDSirolimus inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of STAT3 protein]PMID:26648565
Stat3decreases phosphorylationISOSTAT3 (Homo sapiens)6480464CTDSirolimus results in decreased phosphorylation of STAT3 proteinPMID:20038814
Stat3multiple interactionsISOSTAT3 (Homo sapiens)6480464CTDSirolimus inhibits the reaction [IFNG protein results in decreased phosphorylation of STAT3 protein]PMID:16427044
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