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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2366 Species: Rattus norvegicus RGD Object: Gene Symbol: Abcc2 Name: ATP-binding cassette, subfamily C (CFTR/MRP), member 2

Acc ID: CHEBI:9168 Term: sirolimus Definition: A macrolide isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent. CasRN: 53123-88-9 Chemical ID: MESH:D020123

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	EXP		6480464	CTD	Sirolimus results in decreased expression of ABCC2 mRNA	PMID:11589784