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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1347922 Species: Homo sapiens RGD Object: Gene Symbol: PCK1 Name: phosphoenolpyruvate carboxykinase 1 (soluble)

Acc ID: CHEBI:9168 Term: sirolimus Definition: A macrolide isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent. CasRN: 53123-88-9 Chemical ID: MESH:D020123

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:3267	6480464	CTD	[troglitazone co-treated with Sirolimus] results in decreased expression of PCK1 mRNA	PMID:10446394