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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735389 Species: Homo sapiens RGD Object: Gene Symbol: BBC3 Name: BCL2 binding component 3

Acc ID: CHEBI:9150 Term: simvastatin Definition: A fatty acid ester comprising a dihydroxyheptanoic acid unit condensed into a lactone; a partially reduced naphthalene structure; and a 2,2-dimethylbutyric acyl substituent at C17. It is used as a cholesterol-lowering and anti-cardiovascular disease drug. CasRN: 79902-63-9 Chemical ID: MESH:D019821

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	EXP		6480464	CTD	Simvastatin results in increased expression of BBC3 mRNA Simvastatin results in increased expression of BBC3 protein	PMID:20045437
multiple interactions	EXP		6480464	CTD	Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of BBC3 protein] pifithrin inhibits the reaction [Simvastatin results in increased expression of BBC3 protein] pifithrin inhibits the reaction [Simvastatin results in increased expression of BBC3 mRNA]	PMID:20045437
affects localization	EXP		6480464	CTD	Simvastatin affects the localization of BBC3 protein	PMID:20045437
increases expression	EXP		6480464	CTD	Simvastatin results in increased expression of BBC3 mRNA	PMID:17428261 PMID:21199873 PMID:20045437
increases expression	EXP		6480464	CTD	Simvastatin results in increased expression of BBC3 mRNA	PMID:20045437 PMID:21199873 PMID:17428261
increases expression	EXP		6480464	CTD	Simvastatin results in increased expression of BBC3 mRNA	PMID:17428261 PMID:20045437 PMID:21199873
increases expression	EXP		6480464	CTD	Simvastatin results in increased expression of BBC3 mRNA	PMID:21199873 PMID:17428261 PMID:20045437