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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69328 Species: Rattus norvegicus RGD Object: Gene Symbol: Cdkn1a Name: cyclin-dependent kinase inhibitor 1A

Acc ID: CHEBI:9150 Term: simvastatin Definition: A fatty acid ester comprising a dihydroxyheptanoic acid unit condensed into a lactone; a partially reduced naphthalene structure; and a 2,2-dimethylbutyric acyl substituent at C17. It is used as a cholesterol-lowering and anti-cardiovascular disease drug. CasRN: 79902-63-9 Chemical ID: MESH:D019821

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:735341	6480464	CTD	geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased expression of CDKN1A protein]	PMID:18625202
multiple interactions	ISO	RGD:735341	6480464	CTD	Simvastatin inhibits the reaction [Fluorouracil results in decreased degradation of CDKN1A protein]	PMID:15625077
increases expression	ISO	RGD:735341	6480464	CTD	Simvastatin results in increased expression of CDKN1A mRNA	PMID:18337644
multiple interactions	ISO	RGD:735341	6480464	CTD	[Simvastatin results in decreased degradation of CDKN1A protein] which results in decreased activity of CDK2 protein	PMID:17928568
increases expression	ISO	RGD:735341	6480464	CTD	Simvastatin results in increased expression of CDKN1A protein	PMID:18625202
increases expression	EXP		6480464	CTD	Simvastatin results in increased expression of CDKN1A protein	PMID:18804536
increases expression	ISO	RGD:735341	6480464	CTD	Simvastatin results in increased expression of CDKN1A mRNA	PMID:18337644 PMID:17428261
increases expression	ISO	RGD:735341	6480464	CTD	Simvastatin results in increased expression of CDKN1A protein	PMID:17428261 PMID:18625202
increases expression	ISO	RGD:735341	6480464	CTD	Simvastatin results in increased expression of CDKN1A mRNA	PMID:17428261 PMID:18337644