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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1550157 Species: Mus musculus RGD Object: Gene Symbol: Kras Name: v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog

Acc ID: CHEBI:9150 Term: simvastatin Definition: A fatty acid ester comprising a dihydroxyheptanoic acid unit condensed into a lactone; a partially reduced naphthalene structure; and a 2,2-dimethylbutyric acyl substituent at C17. It is used as a cholesterol-lowering and anti-cardiovascular disease drug. CasRN: 79902-63-9 Chemical ID: MESH:D019821

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases prenylation	ISO	RGD:1350859	6480464	CTD	Simvastatin results in decreased prenylation of KRAS protein	PMID:8063617