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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10551
Species: Mus musculus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1 (alpha)
Acc ID: CHEBI:9144
Term: silibinin
Definition: A flavonolignan isolated from milk thistle, Silybum marianum, that has been shown to exhibit antioxidant and antineoplastic activities.
Chemical ID: MESH:C440975
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1multiple interactionsISOEsr1 (Rattus norvegicus)6480464CTDSilybin results in increased activity of [ESR1 protein binds to ESR2 protein]PMID:16076518
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTDSilybin results in increased activity of [ESR1 protein binds to ESR2 protein]PMID:16076518
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