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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2200 Species: Rattus norvegicus RGD Object: Gene Symbol: Bcl2l1 Name: Bcl2-like 1

Acc ID: CHEBI:9139 Term: sildenafil Definition: A pyrazolo[4,3-d]pyrimidin-7-one having a methyl substituent at the 1-position, a propyl substituent at the 3-position and a 2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl group at the 5-position. CasRN: 139755-83-2 Chemical ID: MESH:C101426

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
affects response to substance	ISO	RGD:735516	6480464	CTD	BCL2L1 protein affects the susceptibility to sildenafil	PMID:20884855
multiple interactions	ISO	RGD:735516	6480464	CTD	sildenafil promotes the reaction [Doxorubicin results in decreased expression of BCL2L1 protein] BCL2L1 protein inhibits the reaction [sildenafil results in increased activity of Doxorubicin]	PMID:20884855